Juglone inhibits the proliferation of human esophageal carcinoma EC1 cells
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چکیده
منابع مشابه
Down-regulating ATDC inhibits the proliferation of esophageal carcinoma cells.
OBJECTIVE Our previous study showed that Ataxia-Telangiectasia Group D Complementing gene (ATDC) expression was correlated with tumor aggressiveness and poor prognosis in patients with esophageal squamous cell carcinoma (ESCC). However, the roles of ATDC on the esophageal carcinoma cells remain unclear. The present study aimed to explore the effects of ATDC gene silencing on the growth and prol...
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Previous studies have demonstrated that the growth of tumor cells may be inhibited by antisense oligonucleotides (ASODNs) targeted against human telomerase (hTR) or human telomerase reverse transcriptase (hTERT), resulting in antitumor activity in a wide variety of tumors. However, few studies have investigated the effect of hTERT gene-targeted ASODNs on telomerase activity and cell proliferati...
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Background: Kinesin spindle protein (KSP) plays a critical role in mitosis. Inhibition of KSP function leads to cell cycle arrest at mitosis and ultimately to cell death. The aim of this study was to suppress KSP expression by specific small-interfering RNA (siRNA) in Hep3B cells and evaluate its anti-tumor activity. Methods: Three siRNA targeting KSP (KSP-siRNA #1-3) and one mismatched-siRNA (...
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متن کاملLuteolin inhibits cell proliferation and induces cell apoptosis via down-regulation of mitochondrial membrane potential in esophageal carcinoma cells EC1 and KYSE450
In current study, we investigated the anti-tumor effect of luteolin in human ESCC cell lines in vitro and in vivo and tried to explore the potential mechanisms. Results from flow cytometry showed that luteolin could induce apoptosis and caspase-3 activation and induce cell cycle arrest at G2/M phase in a dose- and time-dependent manner in EC1 and KYSE450 cells. JC-1 test results showed that mem...
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ژورنال
عنوان ژورنال: World Chinese Journal of Digestology
سال: 2010
ISSN: 2219-2859
DOI: 10.11569/wcjd.v18.i11.1147